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Tretionin is a natural metabolite of retinol that works by suppressing gene expression, which initiates a modification synthesis of proteins. Retin-A cream penetrates the cells (their membranes) and forms complexes with specific cytoplasmic
retionin is a natural metabolite of retinol that works by suppressing gene expression, which initiates a modification synthesis of proteins. Retin-A cream penetrates the cells (their membranes) and forms complexes with specific cytoplasmic receptors that penetrate the cell nucleus and connect with DNA (genetic material). Depending on tissue condition, tretionin inhibits protein synthesis, or activates the process of transcription and increases the number of m-RNA.
Retin-A inhibits the gene transcription factor (AP-I), which makes it possible to achieve cessation or reduction of protein synthesis and smoothes the adverse effects of the sun's rays on the skin (including hyperpigmentation).
Retin-A reduces the adhesion of those cells that participate in the formation of acne vulgaris, prevents the formation of traffic jams (keratin), and increases the synthesis of substances that are similar to glycosaminoglycans in the corneal epithelium. When applied to open wrinkles Retin-A smoothes skin surface without inflammatory attributes.
When Retin A is applied on the closed wrinkles it helps them to become papules or open acne forms. It also prevents the occurrence of new acne. There is evidence that Retin-A inhibits the synthesis of keratin, has antitumor effects and promotes hair growth.
Retin A cream is intended for topical use. The drug is applied to the site of the lesion with a thin layer once daily at bedtime and leave on the skin surface for six hours (for dry skin - only 30 minutes). After that you need to wash your face with tap water. If necessary, you can use cream twice daily. The duration of treatment depends on the type of pathology: therapeutic efficacy in the treatment of acne vulgaris is observed in 14-21 days; in most cases it is required in 42-49 days. Optimal clinical results are observed in 90-day therapy. When Retin A is used to remove the adverse effects from the influence of sunlight positive effect is achieved in the period from 4 to 24 weeks. For prophylaxis Retin-A is used once in seven days after having a bath with warm water. The treatment of flat warts begins with small concentrations. In insufficient effect the dose can be gradually increased.
Try to follow your treatment schedule. If you miss a dose do not use the doubled dose. Apply next evening.
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Always consult with your healthcare professional before ingesting any medication.
The most common Retin A side effects include:
Local reactions: swelling, blisters, dryness and exfoliation of the skin, hypopigmentation, photosensibilisation, allergic reactions - edema, itching, hyperemia, stinging at the site of application
Do not apply the medication if you have any allergic reactions of reactions of hypersensitivity to any of the medication ingredients. Retin A is should not be used in:
Chronic intoxication (including alcoholic intoxication)
Chronic liver failure
Chronic kidney failure
Children under 12 years of age
Pregnancy (retin-A may cause significant damage to the fetus if applied during pregnancy)
should be stored in a cool, dry environment away from sunlight.
Most patients receiving prescriptions today are choosing to purchase generic drugs; A generic drug is a copy that is the same as a brand-name drug in dosage, safety, strength, how it is taken, quality, performance and intended use.
Today, almost half of all prescriptions are filled with Generic medications are less expensive because generic manufacturers don’t have the investment costs of the developer of a new drug. New drugs are developed under patent protection. The patent protects the investment—including research, development, marketing, and promotion—by giving the company the sole right to sell the drug while it is in effect. As patents near expiration, manufacturers can apply to the FDA to sell generic versions. Because those manufacturers don’t have the same development costs, they can sell their product at substantial discounts. Also, once generic drugs are approved, there is greater competition, which keeps the price down.Today, almost half of all prescriptions are filled with generic drugs..
Generic firms have facilities comparable to those of brand-name firms. In fact, brand-name firms are linked to an estimated 50 percent of generic drug production. They frequently make copies of their own or other brand-name drugs but sell them without the brand name.
"Since generic drugs generally sell for less than brand name drugs, many people falsely believe that generics must be inferior to brand-name products. Generic drugs contain exactly the same active ingredients as the brand-name drugs and are just as safe and effective."